Xyliance (INCI: Cetearyl wheat straw glycosides and cetearyl alcohol) is an example of a plant derived and approved for natural cosmetics hot-process emulsifier. Enhancement of stability and skin permeation by sucrose stearate and Im curious to buy it and try it out both ways to see the difference. Hence, using Box-Behnken Design, an attempt was made to optimize the preparation of biocompatible curcumin-loaded niosome based on sucrose stearate as non-ionic surfactant and cholesterol. Another issue with hot process emulsifiers appears when youre working with sensitive plant oils and extracts instead of heat sensitive paraffin, silicone oils and synthetic waxes. Blend phase A in a beaker and set it aside for at least one hour (cover the beaker). Apart from pure liquid crystal emulsifiers (which are, from a physical point of view, usually VERY chaotic and unpredictable), the perfect emulsifier would be added to the interphase (thats the super fine surface between the two phases). Please use the form on the right to contact LisaLise. Govindarajam R, Zinchuk A, Hancock B, Shalaev E, Suryanarayanan R. Ionization states in the microenvironment of solid dosage forms: effect of formulation variables and processing. *** Click on one of the three Forum categories below to start a new discussion ***, Home Cosmetic Science Talk Formulating Sucrose Stearate Cold Process Emulsion. Prepare a 10% dilution of the emulsion in distilled water and measure the pH. Home / Products / Pharmaceutical Excipients / Sucrose stearate. Park, J. Nanomater. Pharmaceutics | Free Full-Text | Semi-solid Sucrose Stearate-Based at the university or in the laboratory), and I am still connected with them today. Salt formation to improve drug solubility. And do you also always add dimethicone? You can however blend all of the water phase from the beginning in one beaker. I know a lot of people which dont like Olivem 1000, but I cant imagine why? Learn how to make a whipped body butter with a gorgeous tuberose and neroli scent. Physical and biological considerations for the use of nonaqueous solvents in oral bioavailability enhancement. I have used 2-3% SS + 2-3% from the others. Authors are thankful to Dineh Iran Industries Complex, Tehran, Iran and Sisterna Company, Roosendaal, Netherlands for providing the gift sample of curcumin and sucrose stearate, respectively. What kind of products (and textures) can I make with sucrose stearate? In this context, the effect of the natural excipients sucrose stearate and cyclodextrins alpha, beta and gamma on in vitro skin permeation was investigated; the influence of the positive particle surface charge induced by . Nevertheless, it worked. PubMed John, C.T., Xu, W., Lupton, L.K. Blend phases B and C separately in two other beakers. AAPS PharmSciTech. As not everyone around the globe can source Sucragel (particularly in the smaller amounts commonly required and desired for artisan cosmetic makers), Im sure you can imagine how much excitement this generated. 10(51), 3078530795 (2020), Article Molecular Weight. In: Borchardt R, editor. Well it takes a little bit time since I publish tutorials after they pass the stability tests which takes at least a couple of months. 2023 Springer Nature Switzerland AG. Google Scholar. Coombes, M. Fitzgerald, Y. Perrie, Int. Both studies saw good discrimination between concentrations . Sucrose stearate has re-greasing and moisturizing properties. 10, 413433 (2017), I.A. Spectrosc. Add preservative, pH adjuster (optimal pH 5 - 5.5), fragrance etc. J Pharm Sci. Magnesium stearate induced the most extensive and rapid disproportionation at 40C/75%RH and 40C/35%RH. With the rise of environmental consciousness and the demand for sustainability as well as the industrial demand for time and energy saving procedures, it seems that these hot process emulsifiers, although still quite effective, are not necessarily as attractive as they used to be. Thank you. Sucrose Stearate is one of those amazing emulsifiers that enables you to create low viscosity and sprayable emulsions. In nature, sucrose is found in most fruits and vegetables while stearic acid is a fatty acid found in high concentrations in some plant butters, like shea and cocoa butter. You can even replace your entire water phase with herbal infusions or hydrosols without being concerned that your precious herbal active ingredients will be damaged by heating your lotion up to 75 degrees. New York: Springer; 2006. p. 10030. 66(1), 222307 (2014), Article J Chem Phys. It is fascinating to talk to people who are "on fire" for their field and to feel their enthusiasm to pass on this knowledge. 2019-2022 by LAB NOTES - Formulator's diary. Ive tried applying high shear for 1-2 minutes before adding the gum, after adding the gum, tried changing the preservative and I still get the same results. PubMed This study was supported by Ferdowsi University of Mashhad (FUM), Mashhad, Iran (Grant Number 48187). Control. Energy support from essential B-vitamins. Battula, R. Kandasamy, G.A. Do you generally find Olivem 1000 works best with low levels of oil? The NIR and XRPD results for the sucrose stearate, crospovidone, and stearic acid compacts did not show any detectable HCl salt disproportionation. You get a different skin sensorial. We love receiving your emails. Incorporate fully before the next addition. Skin Care: Transforming Comfort Mask by DSM. The motivation for my research was and is a harmonious, sensible, physiological and resource-saving skin care. You just have to follow the right procedure and match it with ingredients that boost the formula stability and voila - the emulsions created with sucrose stearate are easy to make, provide gorgeous skin benefits and enable the formulation of a wide range of skincare products. Mehdi Varidi. 10, 180190 (2018), Article 2000;16:508692. In nature, sucrose is found in most fruits and vegetables. Pharm. So, change your procedure to first add Xanthan/Glycerin to water stirring to hydrate the Xanthan. Please join me in welcoming the lovely and talented Heike Kser of Olionatura ! J Pharm Sci. Zannou EA, Ji Q, Joshi YM, Serajuddin ATM. Most of them were only available in the USA. Next batch, I will be playing with both percentages and ingredients to see which kinds of additional textures can be created. Bone health support from vitamin D. Not too little. 2008;5(6):10139. Christopher T. John or Paul A. Harmon. What we mean by this is that you only need to heat up a part of your emulsion and then process the rest at room temperature. Do you think Olivem 900 (sorbitan olivate on its own) should also be added first to water when using as a co emulsifier? Sucrose stearate based niosomes as an alternative to Pharm. Macromol. Now lauric acid is a C-12 fatty acid, and stearic acid (both are the starting materials for the esters) is a C-18 fatty acid - it was to be assumed that the result would not be identical. Article Xu, W.R. Chen, K.J. I have some coming in the mail. Solid-state interaction of magnesium oxide and ibuprofen to form a salt. Used bamix to homogenise for about 1.5 minutes. She has over 20 years industry experience and is based in Bavaria, Germany. thank you for helping though . 4.7. If you're using another preservative, adjust the pH according to your preservative. McClements, Current opinion in food. In contrast, the NIR data indicates that the compacts containing sodium croscarmellose (solid diamond, solid line), sodium stearyl fumarate (solid square, solid line) and magnesium stearate (solid . By subscribing you accept our. Read our. Second, even if the emulsifier is the right one, it is quite challenging to achieve the right balance to create a "stable" emulsion. Hot process usually creates stable emulsions with a small particle size. On top of that: I just love to learn :-) Pressing fresh oils, making extracts, distilling plants, conceiving new product ideas all this is creativity and sensuality in beautiful combination. You might even have heard of a cold process emulsion. 13, 123133 (2001), R.M. your institution. Continue stirring for a few further minutes until the gum is completely blended. Dr. Elham Eghbali was Formula Botanicas Cosmetic Chemist between 2014 and 2018. Gone are the days of destroying the beautiful botanical properties of your hydrosols, oxidising your exotic oils and rendering your high performance cosmeceuticals inactive. The important thing here is the viscosity of the emulsion, which is more liquid than these made with Olivem into the oil phase. This is a preview of subscription content, access via The formulations made with sucrose stearate provide a protective barrier on the skin to retain moisture and reduce the feeling of irritation. PubMed Follow the steps below to create our Cherry & Pomegranate Sprayable Body Lotion: Enrol for Formula Botanicas Diploma in Organic Skincare Formulationto become a professional organic skincare entrepreneur. 2007;59:60316. :-). Kararli TT, Needham TE, Seul CJ, et al. Although this benefit is particularly significant when you are manufacturing at a large scale and producing large batches of lotion, it can still be an advantage even in your small artisanal lab (want to learn how to upscale your manufacturing and outsource to an external lab?). El-Say, J. Pharm. Mahran, Eur J Pharm Biopharm. Today I am happy to see how much has grown from this. XLogP3. Once upon a time, there was only and only one way to create an emulsion: There are still thousands of emulsifiers that work this way and basically there is nothing wrong with them. It containsBRB 1860 which provides high conditioning on hair as well as repairs and protects from external damage. Akoh, Food Funct. Can someone tell me what is causing this please? 89, 199212 (2003), M.S. There are still thousands of emulsifiers that work this way and basically there is nothing wrong with them. Gao P, Morozowich W. Development of supersaturable self-emulsifying drug delivery system formulations for improving oral absorption of poorly soluble drugs. Also, out of interest, do you prefer adding Olivem 1000 in the water phase rather than the oil phase? Afterwards, you could blend this heated phase with your other phases which are at room temperature. 30, 25122522 (2013), V. Sharma, S. Anandhakumar, M. Sasidharan, Mater. Cantrell W, McCrory C, Ewing G. Nucleated deliquescence of salt. The second, and most important advantage for organic skincare formulators is the ability to work with hydrosols, plant extracts and heat sensitive plant oils. mystric, palmitate, and oleate) and found maximal e cacy with sucrose stearate and SL (L-1695), both at a concentration 0.5% w / v . Why I shared the formulation or the idea? Sucrose Stearate (Emulsifier): Cosmetic Ingredient INCI Naik, J. Mol. Hydrogen Bond Donor Count. 2008;97:107188. It contains BRB 1860 which provides high conditioning on hair as well as repairs and protects from . I started developing my current concept in 2006. If you want to apply high concentrations of a heat sensitive ingredient, then a cold process emulsion or a hot cold process emulsion might be a better choice than a hot process emulsion. Disperse SS in coconut oil, added water and whisk to emulsify. Elham Eghbali was Formula Botanicas Cosmetic Chemist between 2014 and 2018. ROSE & VANILLA: Dual-purpose soothing lotion with oat silk, If you would love to learn how to create a lovely, stable emulsion made with sucrose stearate that is appropriate for the body and face, cold-processed and has a light, gel-cream/lotion/yogurt texture, you can find the formula in my, Your privacy is important to us. What kind of products (and textures) can I make with sucrose stearate? Pharmaceutical Preparations, Excipients, Formulation - CD Formulation. Fouda, A.M. Donia, American Association of Pharmaceutical Scientists. And now, with Heikes gracious permission, I am thrilled to present you with her formulation guide for this Sucragel-style emulsifier which I have named Sugar Ester Emulsifier. 5 kg) then heating and cooling might not be a big issue for you. CAS Adv Drug Deliv Rev. There is no soapiness, no stickiness and no "maccaroni effect". If you are working with high concentrations of waxes, butters and fatty alcohols, then a hot process emulsion may be a better solution for you than a cold process emulsion. Google Scholar. Dont whisk and use Bamix fully immersed so theres no air getting sucked into your emulsion. Leave the Emulsion for 14 hours to settle and fill it in a suitable bottle. (PDF) pharmaceutics Evaluation of Sucrose Laurate as an Intestinal PubMed Central 25(3), 721727 (2016), Article 4, 501510 (2014), PubMed Formulating with Sucrose Stearate: A must-have emulsifier in your lab. Learn more about Institutional subscriptions. J. Pharm. 2007;10(3):1049. Drug delivery strategies for poorly water-soluble drugs. 77, 4355 (2011), J.S. CAS Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. J Aerosol Sci. Choose oils that are stable and have a long shelf life to make your emulsifier such as jojoba, meadowfoam, squalene, and neutral oils. 1(2) (2001), N.D. Machado, M.A. Tax calculation will be finalised during checkout. Najafi, M. Baghaie, A. Ashori, Int. Below is the link to the electronic supplementary material. If you add a little Dimethicone you will get a great summer moisturizer, which is breathable, light with fantastic softening properties. Adeyeye M. C. and Brittain H.G. Nine common excipients were examined to determine their ability to cause disproportionation of the HCl salt of a a weakly basic compound. Can you imagine how much time and energy it takes to heat up about 5 tons of water and then cool that amount after the emulsification process?